| 2022-05-21 15:00:04May 21, 2022 | Marumo Gallants FC  | 2 - 2 |  Sekhukhune United FC | 15:00:043:00 pm | New Peter Mokaba Stadium |
| 2022-05-14 15:00:07May 14, 2022 | Sekhukhune United FC | 0 - 1 |  Kaizer Chiefs | 15:00:073:00 pm | Emirates Airline Park |
| 2022-05-07 17:00:08May 7, 2022 | AmaZulu  | 0 - 0 | Sekhukhune United FC | 17:00:085:00 pm | Moses Mabhida Stadium |
| 2022-05-03 17:30:22May 3, 2022 | Sekhukhune United FC | 0 - 2 |  Mamelodi Sundowns | 17:30:225:30 pm | Emirates Airline Park |
| 2022-04-23 15:00:20April 23, 2022 | Golden Arrows  | 0 - 0 | Sekhukhune United FC | 15:00:203:00 pm | Princess Magogo Stadium |
| 2022-04-16 15:00:59April 16, 2022 | Sekhukhune United FC | 0 - 1 |  TS Galaxy | 15:00:593:00 pm | Makhulong Stadium |
| 2022-04-06 17:30:37April 6, 2022 | Sekhukhune United FC | 0 - 1 |  Orlando Pirates | 17:30:375:30 pm | Emirates Airline Park |
| 2022-04-02 15:00:47April 2, 2022 | Stellenbosch FC  | 1 - 1 | Sekhukhune United FC | 15:00:473:00 pm | Danie Craven Stadium |
| 2022-03-16 17:30:53March 16, 2022 | Sekhukhune United FC | 1 - 1 |  Maritzburg United | 17:30:535:30 pm | Emirates Airline Park |
| 2022-03-05 17:00:14March 5, 2022 | Cape Town City FC  | 2 - 1 | Sekhukhune United FC | 17:00:145:00 pm | Cape Town Stadium |
| 2022-02-26 17:30:24February 26, 2022 | Sekhukhune United FC | 0 - 1 |  Moroka Swallows | 17:30:245:30 pm | Emirates Airline Park |
| 2022-02-20 18:00:35February 20, 2022 | Sekhukhune United FC | 4 - 0 |  Baroka | 18:00:356:00 pm | Emirates Airline Park |
| 2022-02-15 17:30:16February 15, 2022 | Royal AM  | 1 - 0 | Sekhukhune United FC | 17:30:165:30 pm | Chatsworth Stadium |
| 2022-02-12 15:00:57February 12, 2022 | Platinum City Rovers  | 1 - 1 | Sekhukhune United FC | 15:00:573:00 pm | Olen Park Stadium |
| 2021-12-22 17:00:15December 22, 2021 | Chippa United  | 0 - 0 | Sekhukhune United FC | 17:00:155:00 pm | Nelson Mandela Bay Stadium |
| 2021-12-18 18:00:27December 18, 2021 | Sekhukhune United FC | 0 - 0 |  Supersport United | 18:00:276:00 pm | Emirates Airline Park |
| 2021-12-12 18:00:39December 12, 2021 | Kaizer Chiefs | 2 - 0 | Sekhukhune United FC | 18:00:396:00 pm | FNB Stadium |
| 2021-12-08 17:00:49December 8, 2021 | Sekhukhune United FC | 0 - 1 | Marumo Gallants FC | 17:00:495:00 pm | Emirates Airline Park |
| 2021-12-05 15:30:32December 5, 2021 | Supersport United | 0 - 1 | Sekhukhune United FC | 15:30:323:30 pm | Lucas Moripe Stadium |
| 2021-11-27 15:30:53November 27, 2021 | Mamelodi Sundowns | 2 - 0 | Sekhukhune United FC | 15:30:533:30 pm | Loftus Versfeld Stadium |
| 2021-11-20 17:30:58November 20, 2021 | Sekhukhune United FC | 1 - 0 | Royal AM | 17:30:585:30 pm | Emirates Airline Park |
| 2021-11-07 15:30:12November 7, 2021 | Moroka Swallows | 0 - 1 | Sekhukhune United FC | 15:30:123:30 pm | Dobsonville Stadium |
| 2021-11-02 17:00:11November 2, 2021 | Orlando Pirates | 2 - 1 | Sekhukhune United FC | 17:00:115:00 pm | Orlando Stadium |
| 2021-10-23 15:30:17October 23, 2021 | Sekhukhune United FC | 2 - 0 | AmaZulu | 15:30:173:30 pm | Emirates Airline Park |
| 2021-10-16 15:30:21October 16, 2021 | Sekhukhune United FC | 1 - 0 | Cape Town City FC | 15:30:213:30 pm | Emirates Airline Park |
| 2021-10-02 15:30:28October 2, 2021 | TS Galaxy | 0 - 1 | Sekhukhune United FC | 15:30:283:30 pm | Mbombela Stadium |
| 2021-09-25 15:00:27September 25, 2021 | Sekhukhune United FC | 1 - 1 | Golden Arrows | 15:00:273:00 pm | Emirates Airline Park |
| 2021-09-18 17:00:08September 18, 2021 | Baroka | 1 - 0 | Sekhukhune United FC | 17:00:085:00 pm | New Peter Mokaba Stadium |
| 2021-09-11 17:00:05September 11, 2021 | Sekhukhune United FC | 1 - 1 | Stellenbosch FC | 17:00:055:00 pm | Emirates Airline Park |
| 2021-08-25 17:00:06August 25, 2021 | Maritzburg United | 0 - 2 | Sekhukhune United FC | 17:00:065:00 pm | Harry Dwala Stadium |
